41
5
317
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14941 |
CGP37157
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one |
Na+/Ca2+ Exchanger | Membrane transporter/Ion channel |
CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) 是一种 Na+/Ca2+ 交换抑制剂,抑制 Na+ 诱导的豚鼠心脏线粒体中 Ca2+ 的释放,IC50 为 0.8 μM。 | |||
T16564 |
PPADS tetrasodium
|
P2X Receptor; Na+/Ca2+ Exchanger | Membrane transporter/Ion channel; Neuroscience |
PPADS tetrasodiuma 是一种有效的 P2X 受体拮抗剂,也是是豚鼠气道平滑肌 Na/Ca²⁺ 交换逆模式的抑制剂,对谷氨酸/NMDA毒性有神经保护作用。PPADS tetrasodiuma 抑制 P2X1、P2X-2、P2X-3 和 P2X-5。 | |||
TP1572 |
GR-73632
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
GR-73632 强效和选择性速激肽 NK1 受体激动剂,可通过传递瘙痒信号的 NK1 受体直接作用于初级感觉神经元的外周末端。 | |||
T25010 |
AK-2-38
AK -2-38,AK2-38 |
||
AK-2-38 is a nifedipine analogue with potent smooth muscle calcium antagonist action and partial agonist effects on isolated guinea pig left atrium. | |||
T10360 |
AR-A 2
AR-A 000002 |
Others | Others |
AR-A 2 is a selective 5-HT1B receptor antagonist, with a high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM). | |||
T68904 | GW-833972A free base | ||
GW833972 is a CB2 Agonist. GW 833972A inhibited capsaicin-induced depolarization of the human and guinea-pig and prostaglandin E(2) (PGE(2)) and hypertonic saline-induced depolarization of the guinea-pig isolated vagus nerve in vitro. GW 833972A also inhibited citric acid-induced cough but not plasma extravasation in the guinea-pig and this effect was blocked by a CB(2) receptor antagonist. | |||
T27435 |
GS 283
GS283,GS-283 |
||
GS 283 is a Ca(2+) antagonist. GS 283 is also a weak histamine and muscarinic receptor blocker in rat and guinea pig tracheal smooth muscles. | |||
T8437 | 3-(4-prop-2-en-1-ylpiperazin-1-yl)quinox | Others | Others |
3-(4-prop-2-en-1-ylpiperazin-1-yl)quinox 拮抗 2-methyl-5-HT 诱导的豚鼠回肠收缩。 | |||
T27140 |
Delequamine HCl
RS-15385,RS15385,RS 15385,Delequamine,RS-15385-197 |
||
Delequamine HCl is a potent and selective alpha 2-adrenoceptor antagonist. Delequamine HCl has a pKi of 9.45 for alpha 2-adrenoceptors in the rat cortex (pA2 in the guinea-pig ileum of 9.72). | |||
T68495 |
Ganciclovir triphosphate
|
||
Ganciclovir triphosphate is a synthetic analog of 2'-deoxy-guanosine which is used to treat or prevent cytomegalovirus (CMV) infections. It inhibits the replication of human CMV with an IC50 value of 0.01 μM and is effective against strains of CMV from human, monkey, mouse, and guinea pig. | |||
T71088 | AM-211 sodium | ||
AM-211 sodium is a novel and potent antagonist of the prostaglandin D2 receptor type 2. AM-211 is active in animal models of allergic inflammation. AM211 has high affinity for human, mouse, rat, and guinea pig DP2 and it shows selectivity over other prostanoid receptors and enzymes. AM211 exhibits good oral bioavailability in rats and dogs and dose-dependently inhibits 13,14-dihydro-15-keto-PGD(2)-induced leukocytosis in a guinea pig pharmacodynamic assay. | |||
T81079 |
Substance P (2-11)
|
||
Substance P (2-11)为P物质(SP)片段肽,具有对豚鼠回肠产生收缩活性的特性。同时,Substance P (2-11)能够抑制3H SP在BBMEC单分子层中的渗透。 | |||
T35627 |
Amylin (human) (trifluoroacetate salt)
|
||
Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. It binds to amylin receptors with IC50 values of 2 and 0.2 nM for porcine and guinea pig nucleus accumbens membrane preparations, respectively. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes. Amylin forms fibrils that react to thioflavin T and are organized in a cro... | |||
T80866 |
VIP(Guinea pig) TFA
Vasoactive Intestinal Peptide, guinea pig TFA |
||
VIP Guinea pig TFA,作为一种胃肠激素,兼具神经递质功能,能够刺激胚胎生长,起到营养和有丝分裂因子的作用。 | |||
T32007 |
GSK256471
GSK 256471,GSK-256471 |
||
GSK256471 is a potent selective NK(3) antagonist that shows a high affinity for recombinant human (PK (I) value 8.9) and native guinea pig (PK (I) value 8.4) tachykinin NK(3) receptors. In vitro functional assessment showed that GSK256471 reduced the E(Ma | |||
T76063 |
Beta-defensin 1, pig
|
||
Beta-defensin 1, pig 是一种在猪舌黏膜中主要发现的抗菌肽,对包括大肠杆菌、鼠伤寒沙门氏菌、单核细胞增生性李斯特菌、金黄色葡萄球菌、百日咳博德特氏菌和白色念珠菌在内的多种细菌显示出活性。 | |||
T26781 |
BF-1
BF1 |
||
BF-1 is a 5-Hydroxytryptamine receptor 2B antagonist. BF-1 was tested as potential migraine prophylactic drug by blocking BW723C86 (5-((thiophen-2-yl)methoxy)-α-methyltryptamine) or meta-chlorophenylpiperazine (mCPP) induced neurogenic dural plasma protei | |||
T23154 |
Piclamilast
RPR 73401,RP 73401,吡拉米司特 |
PDE | Metabolism |
Piclamilast (RP 73401) 是一种有效的磷酸二酯酶 4(PDE4)的抑制剂,对猪主动脉和可溶性嗜酸性粒细胞中的 IC50值分别为 16 nM 和 2 nM。 | |||
T70514 |
Ganciclovir monophosphonate
|
||
Ganciclovir monophosphonate is a synthetic analog of 2'-deoxy-guanosine which is used to treat or prevent cytomegalovirus (CMV) infections. It inhibits the replication of human CMV with an IC50 value of 0.01 μM and is effective against strains of CMV from human, monkey, mouse, and guinea pig. | |||
T81078 |
Substance P (3-11)
|
||
Substance P (3-11),作为P 物质 (SP) 的片段肽,具备穿透血脑屏障的能力,且对豚鼠回肠显示出收缩活性。 | |||
T76063L |
Beta-defensin 1, pig TFA
|
||
Beta-defensin 1, pig TFA 是一种在猪舌黏膜中主要发现的抗菌肽,对多种细菌如大肠杆菌、鼠伤寒沙门氏菌、单核细胞增生性李斯特菌、金黄色葡萄球菌、百日咳博德特氏菌和白色念珠菌等显示出抗菌活性。 | |||
T32004 |
GSK172981
GSK 172981,GSK-172981 |
||
GSK172981 is a non-peptide tachykinin NK3 receptor antagonist with a high affinity for the recombinant human (PK (I) value 7.7) and native guinea pig (PK (I) value 7.8) tachykinin NK3 receptor. In vitro, the functional evaluation showed that GSK172981 was | |||
T37718 |
Galanin (rat, mouse) (trifluoroacetate salt)
GAL (rat, mouse),Galanin (rat, mouse) (trifluoroacetate salt) |
||
Galanin is a neuropeptide with diverse biological activities. [1][2][3][4][5] It binds to rat galanin (GAL) receptor subtypes GAL1-3 (IC50s = 0.339, 1.35, and 3.31 nM, respectively) and human GAL1-3 (IC50s = 0.288, 1.62, and 12.3 nM, respectively). [1] Galanin binds to and inhibits contraction of guinea pig gastric smooth muscle cells induced by carbachol . [2] In vivo, Galanin (6 nmol, i.c.v.) increases feeding behavior in rats and increases latency to hindpaw withdrawal in response to heat and... | |||
T83497 |
[D-Pro2,D-Phe7,D-Trp9] Substance P
|
||
[D-Pro2,D-Phe7,D-Trp9]Substance P为Substance P的模拟物,并充当其抑制剂,能间接收缩豚鼠回肠。 | |||
T76093 |
Peptide YY (pig)
|
||
Peptide YY (pig) 是一种由36个氨基酸组成的胃肠肽,源自猪的十二指肠。该化合物通过激活Y2 receptor来降低食欲和食物摄入量,主要在胰腺的内分泌细胞中发现,对肠动力和心血管系统具有重要影响。 | |||
T37707 |
14-Anhydrodigitoxigenin
|
||
14-Anhydrodigitoxigenin is a cardenolide and a derivative of digitoxin.1 It reduces the activity of guinea pig heart Na+/K+-ATPase by 15% when used at a concentration of 10 μM.2 | |||
T60340 |
ROS 234
|
||
ROS 234 is a highly effective H3 antagonist, demonstrating a strong binding affinity (pK B) of 9.46 for the Guinea-pig ileum H3 receptor and a pKi of 8.90 for the Rat cerebral cortex H3 receptor. Additionally, it exhibits an ex vivo ED50 of 19.12 mg/kg (ip) in the Rat cerebral cortex. It should be noted that ROS 234 demonstrates limited central access, as reported in [1] and [2]. | |||
T71155 | NP-1815-PX | P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
NP-1815-PX是一种选择性P2X4R拮抗剂,显示出抗炎活性并可缓解慢性疼痛模型的疼痛症状。此外,NP-1815-PX能够抑制豚鼠气管/支气管平滑肌(TSM和BSM)的收缩。 | |||
T60419 | Cyclic HPMPC | ||
Cyclic HPMPC 是有效的抗病毒剂,可以增加感染致死性牛痘苗病毒 (IHD 株) 小鼠的动脉氧饱和度水平。用 Cyclic HPMPC 治疗可改善先天性豚鼠巨细胞病毒 (GPCMV) 感染的结果并减少豚鼠模型中的病毒复制。 | |||
T39176 |
PB28
|
||
PB28 is a cyclohexylpiperazine derivative that functions as a potent and highly selective agonist of the sigma 2 (σ2) receptor, exhibiting a Ki (binding affinity) of 0.68 nM. At the same time, PB28 acts as an antagonist of the sigma 1 (σ1) receptor, with a Ki of 0.38 nM. PB28 demonstrates a lower affinity for other receptors. It effectively inhibits electrically evoked twitch in both the guinea pig bladder (EC50 value of 2.62 μM) and ileum (EC50 value of 3.96 μM). Moreover, PB28 exhibits the abi... | |||
T37330 |
Pyridindolol
|
||
Pyrindolol is a bacterial metabolite that has been found inS. alboverticillatus.1It inhibits neutral β-galactosidase by 50% under acidic, but not neutral, conditions when used at a concentration of 2 μg/ml. It is selective for β-galactosidase isolated from bovine liver over β-galactosidases isolated from human, bovine, pig, and rat tissues and sialidases isolated fromC. perfringens,Streptomyces, and the H3N2 strain of influenza virus (IC50s = >250 μg/ml for all).1,2 1.Aoyagi, T., Kumagai, M., Ha... | |||
T78096 |
BQ-3020 ammonium
|
Endothelin Receptor | GPCR/G Protein |
BQ-3020 ammonium 是一种内皮素受体(endothelin receptor)(ETB receptor) 激动剂。它在阻断[125I]ET-1与猪小脑ETB受体的结合实验中显示出IC50值为0.2 nM。此外,BQ-3020 ammonium能够引致兔肺动脉血管收缩以及猪膀胱颈的松弛,因此可作为心血管疾病研究的工具。 | |||
T76356 |
Neuropeptide Y (2-36) (porcine)
|
||
Neuropeptide Y (2-36) (porcine) 是一种具有 97.14% 与大鼠/人类同源性的猪源性神经肽。作为一种大鼠神经肽受体激动剂,其对Y5、Y2和Y1受体的EC50值为1.2, 1.6 和 3.4 nM,能显著增加食物摄入量,适用于肥胖和饮食失调研究。 | |||
T36152 |
14S(15R)-EET
|
||
14S(15R)-EET is an oxylipin and a cytochrome P450 metabolite of arachidonic acid .114S(15R)-EET binds to isolated guinea pig monocytes with a Kivalue of 612.5 nM in a competitive binding assay using [3H]14(15)-EET.2It induces dilation of precontracted isolated canine epicardial arterioles (EC50= 4 pM) and denuded porcine subepicardial arterioles (EC50= 3 pM).3Unlike 14R(15S)-EET, 14S(15R)-EET does not inhibit COX in enzyme assays or isolated platelets.4 1.Daikh, B.E., Lasker, J.M., Raucy, J.L., ... | |||
T36618 |
Rupatadine
|
||
Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4). It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in hu... | |||
T69230 | AZD-1236 | ||
AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished ... | |||
T75868 | JMV 449 acetate | ||
JMV 449 acetate 是一种有效的神经降压素受体 (neurotensin receptor) 激动剂。JMV 449 acetate 显示抑制125I-neurotensin 与新生小鼠脑结合的 IC50为 0.15 nM,对收缩豚鼠回肠的 EC50为 1.9 nM。JMV 449 acetate 对小鼠具有高效、持久的降温和缓解疼痛作用。 | |||
T36241 |
Arecaidine propargyl ester (hydrobromide)
|
||
Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0.977, and 0.933 μM, respectively). Arecaidine propargyl ester induces contractions in isolated guinea pig atrium (pD2= 8.67). It induces apoptosis and the production of reactive oxygen species (ROS) in U87 and U251 glioblastoma cells when used at a concentration of 100 μM.2Arecai... | |||
T83785 |
2-Chloroadenosine-5'-O-diphosphate sodium
2-chloro ADP |
||
2-Chloroadenosine-5'-O-diphosphate是一种腺苷5'二磷酸(ADP)的衍生物。它在浓度依赖性的方式下,促进了人类富含血小板的血浆中的聚集,并抑制了由前列腺素E2(PGE2)诱导的环磷酸腺苷(cAMP)的产生。2-Chloroadenosine-5'-O-diphosphate引起预收缩的孤立的豚鼠taenia coli条带放松(pD2 = 6.74),降低大鼠的动脉血压。此外,它还抑制了热休克蛋白70(Hsp70)家族成员mortalin的ATP酶活性(人类酶的表观Ki = 45.05 µM)。 | |||
T38100 |
Betamethasone 21-phosphate (sodium salt hydrate)
|
||
Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered top... | |||
T37728 | Methoctramine (hydrate) | ||
Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).[1] It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, respectively). In vitro, methoctramine inhibits acetylcholine-induced reductions in isolated guinea pig tracheal tube contractions when used at a concentration of 1 μM.[2] In vivo, methoctramine inhibits bradycardia and bronchoconstriction induced by acetylcholinein guinea pigs wit... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6S2025 |
8-O-Acetylharpagide
8-O-乙酰哈巴苷,8-Acetylharpagide,3-Acetylharpagide,Acetylharpagide,8-O-Acetylharpagide |
Antibacterial | Microbiology/Virology |
8-O-Acetylharpagide 是从 Ajuga reptans 中分离得到的一种环烯醚萜,有抗肿瘤、抗病毒、抗菌和抗炎作用。它对豚鼠的离体平滑肌有生物活性。 | |||
T4S1422 |
Praeruptorin E
白花前胡素 E,白花前胡素E |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Praeruptorin E 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.2。 | |||
T6S0033 |
Crotonoside
巴豆苷;异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE |
Others; FLT; HDAC | Angiogenesis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others; Tyrosine Kinase/Adaptors |
Crotonoside (Isoguanosine) 是从中草药巴豆中分离出来的一种天然产物。 它抑制 FLT3 和 HDAC3/6,有治疗急性髓性白血病 (AML)的研究潜力。 | |||
T3S2259 |
Methyl eugenol
4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物,存在于植物叶子、果实、根茎中,当植物相应的部位因食草动物进食而受损时,就会释放。它可用于消灭雄性东方果蝇。 | |||
T4S0083 |
Protostemonine
|
Others | Others |
Protostemonine 是一种主要从 Stemona sesslifolia 根中分离得到的生物碱,对哮喘及革兰氏阴性菌所致急性肺损伤有抗炎作用。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00742 |
EGFR Protein, Human, Recombinant (His)
mENA,NISBD2,ERBB1,HER1,PIG61,ERBB,epiderma... |
Human | HEK293 Cells |
EGFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.8 kDa and the accession number is P00533-1. | |||
TMPY-04529 |
EGFR Protein, Human, Recombinant (aa 668-1210, His & GST)
epidermal growth factor receptor,PIG61,ERBB1,NISBD<... |
Human | Baculovirus Insect Cells |
EGFR Protein, Human, Recombinant (aa 668-1210, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.1 kDa and the accession number is P00533-1. | |||
TMPJ-01114 |
GAMT Protein, Human, Recombinant (His)
Guanidinoacetate N-methyltransferase,TP53I2,PIG... |
Human | E. coli |
GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of ... | |||
TMPY-04025 |
CEP57 Protein, Human, Recombinant (GST)
MVA2,PIG8,TSP57,centrosomal protein 57kDa |
Human | E. coli |
CEP57 is a centrosomal protein and is involved in nucleating and stabilizing microtubules. CEP57 was initially identified as a regulator of centriole overduplication in an RNA interference screen. There is a link between altered microenvironmental signaling cues such as FGF-2 overexpression and mitotic instability and provide a rationale for the therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer. CEP57 is involved in intracellular transport processes, and its overexpression c... | |||
TMPY-06549 |
EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-378, His)
ERBB,epidermal growth factor receptor,HER1,mENA,ERBB1,PI... |
Human | HEK293 Cells |
EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-378, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.09 kDa and the accession number is NP_001333870.1. | |||
TMPY-05612 |
EGFR Protein, Human, Recombinant (aa 1-645, His & Avi), Biotinylated
mENA,PIG61,HER1,ERBB1,ERBB,NISBD2,epiderma... |
Human | HEK293 Cells |
EGFR Protein, Human, Recombinant (aa 1-645, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 71.9 kDa and the accession number is P00533-1. | |||
TMPY-05258 |
EGFR Protein, Human, Recombinant (Isoform Viii, hFc)
NISBD2,epidermal growth factor receptor,ERBB,PI... |
Human | Baculovirus Insect Cells |
EGFR Protein, Human, Recombinant (Isoform Viii, hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 65.1 kDa and the accession number is NP_001333870.1. | |||
TMPK-00692 |
EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated
EC 2.7.10.1,PIG61,NISBD2,HER1,mEN... |
Human | HEK293 Cells |
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated is exp... | |||
TMPK-00691 |
EGFRVIII Protein, Human, Recombinant (His & Avi)
EGFR,ErbB,mENA,HER1,LEGFR,EC 2.7.10.1,PIG6... |
Human | HEK293 Cells |
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi) is expressed in HEK2... | |||
TMPK-00689 |
EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled
EC 2.7.10.1,EC 2.7.10,ERBB1,EGFR,mENA,NISB... |
Human | HEK293 Cells |
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled is expre... | |||
TMPY-05211 |
EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-375, His)
NISBD2,PIG61,ERBB,mENA,epidermal growth fa... |
Human | Baculovirus Insect Cells |
EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-375, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 39.3 kDa and the accession number is NP_001333870.1. | |||
TMPY-01043 |
EGFR Protein, Human, Recombinant (hFc)
ERBB,mENA,HER1,ERBB1,PIG61,NISBD2,epiderma... |
Human | HEK293 Cells |
EGFR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95 kDa and the accession number is P00533-1. | |||
TMPY-05637 |
EGFR Protein, Human, Recombinant (aa 1-378, His & Avi), Biotinylated
epidermal growth factor receptor,HER1,mENA,ERBB1,ERBB,NISBD<... |
Human | Baculovirus Insect Cells |
EGFR Protein, Human, Recombinant (aa 1-378, His & Avi), Biotinylated is expressed in Baculovirus insect cells with His and Avi tag. The predicted molecular weight is 41.8 kDa and the accession number is NP_001333870.1. | |||
TMPY-06593 |
EGFR Protein, Human, Recombinant (Isoform vIII, His & Avi), Biotinylated
PIG61,ERBB1,ERBB,NISBD2,epidermal growth f... |
Human | HEK293 Cells |
EGFR Protein, Human, Recombinant (Isoform vIII, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 41.90 kDa and the accession number is NP_001333870.1. | |||
TMPK-00425 |
EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled
EC 2.7.10.1,HER1,EGFR,PIG61,LEGFR,ErbB,ERB... |
Human | HEK293 Cells |
EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.5 kDa and the accession number is P00533-1. | |||
TMPK-00426 |
EGFR Protein, Human, Recombinant (His & Avi)
PIG61,mENA,NISBD2,EC 2.7.10.1,HER... |
Human | HEK293 Cells |
EGFR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.5 kDa and the accession number is P00533-1. | |||
TMPK-00427 |
EGFR Protein, Human, Recombinant (His & Avi), Biotinylated
PIG61,ERBB,LEGFR,mENA,EC 2.7.10.1,EGFR,EC ... |
Human | HEK293 Cells |
EGFR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.5 kDa and the accession number is P00533-1. | |||
TMPK-00902 |
EGFR Protein, Rhesus macaque, Recombinant (His)
HER1,EC 2.7.10,EGFR,NISBD2,ErbB,PIG |
Rhesus | HEK293 Cells |
EGFR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 69.8 kDa and the accession number is P55245. | |||
TMPK-00690 |
EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled
LEGFR,ERBB1,EGFR,HER1,PIG61,NISBD2,EC ... |
Human | HEK293 Cells |
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled is exp... | |||
TMPH-03132 |
AVPR2 Protein, Pig, Recombinant (His & SUMO)
AVPR2,Vasopressin V2 receptor,V2R... |
Sus scrofa (Pig) | E. coli |
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. AVPR2 Protein, Pig, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 24.7 kDa and the accession number is P32307. | |||
TMPH-03111 |
Erythropoietin Protein, Pig, Recombinant (B2M & His)
|
Sus scrofa (Pig) | E. coli |
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Pig, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 32.6 kDa and the accession number is P49157. | |||
TMPY-00612 |
IL-1 beta/IL-1F2 Protein, Sus scrofa (Pig), Recombinant
interleukin 1, β,IL-1 β,interleukin 1, beta |
Sus scrofa (Pig) | E. coli |
IL-1 beta/IL-1F2 Protein, Sus scrofa (Pig), Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.7 kDa and the accession number is P26889. | |||
TMPY-05586 |
CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMIGD2,IGPR-1,transmembrane and immunoglobulin doma... |
Human | HEK293 Cells |
The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent in mouse and rat genomes. The immunoglobulin domain of IGPR-1 was predicted to be Ig V (variable) fold and was found to be highly similar to the Ig domain of myelin-associated glycoprotein.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy. CD28H/TMIGD2 Protein, Hu... | |||
TMPH-03100 |
PMAP-23 Protein, Pig, Recombinant (His & SUMO)
|
Sus scrofa (Pig) | E. coli |
Exerts antimicrobial activity against both Gram-positive and negative bacteria at concentrations of 2-16 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes. PMAP-23 Protein, Pig, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 19.0 kDa and the accession number is P49930. | |||
TMPH-03116 |
IL-4R Protein, Pig, Recombinant (His)
|
Sus scrofa (Pig) | E. coli |
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. IL-4R Protein, Pig, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted mo... | |||
TMPY-01442 |
DMBT1 Protein, Human, Recombinant (His)
GP340,deleted in malignant brain tumors 1,muclin |
Human | HEK293 Cells |
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo... | |||
TMPJ-00850 |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)
Protein T1,suppression of tumorigenicity 2,Ly84,DER... |
Mouse | HEK293 Cells |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2. | |||
TMPY-00891 |
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)
neuropilin 1,VEGF165R,CD304,NP1,Neuropilin-1,NRP,BDCA4 |
Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2. | |||
TMPY-02011 |
CD96 Protein, Human, Recombinant (His)
CD96 molecule,TACTILE |
Human | HEK293 Cells |
CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2. | |||
TMPY-04113 |
KRAS Protein,Human,Recombinant(G12D & Q61H, His)
Kirsten rat sarcoma viral oncogene homolog,KRAS2,KI... |
Human | E. coli |
KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2. | |||
TMPY-01613 |
Periostin/OSF-2 Protein, Mouse, Recombinant (His)
A630052E07Rik,OSF-2,Osf2,PLF,AI74... |
Mouse | HEK293 Cells |
Periostin/OSF-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 89 kDa and the accession number is Q62009-2. | |||
TMPY-01717 |
VEGF164 Protein, Mouse, Recombinant
vascular endothelial growth factor A,Vpf,Vegf,血管内皮生长因子 |
Mouse | Baculovirus Insect Cells |
VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2. | |||
TMPY-02096 |
TACI Protein, Human, Recombinant (His)
RYZN,IGAD2,CVID,TACI,TNFRSF14B,CVID2,tumor... |
Human | HEK293 Cells |
TACI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is O14836-2. | |||
TMPY-00341 |
FGFR3 Protein, Human, Recombinant (alpha IIIb, His)
CEK2,HSFGFR3EX,fibroblast growth factor receptor 3,... |
Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2. | |||
TMPY-06056 |
KRAS Protein, Human, Recombinant (G12D, His)
KRAS1,K-RAS4B,Kirsten rat sarcoma viral oncogene homolog,RAL... |
Human | E. coli |
KRAS Protein, Human, Recombinant (G12D, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P01116-2. | |||
TMPY-00751 |
TrkB Protein, Human, Recombinant (His)
trk-B,GP145-TrkB/GP95-TrkB,neurotrophic tyrosine kinase, rec... |
Human | HEK293 Cells |
TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2. | |||
TMPY-01691 |
Clusterin Protein, Human, Recombinant (CLU34, His)
SGP-2,AAG4,KUB1,CLI,CLU2,TRPM2,AP... |
Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2. | |||
TMPY-04844 |
BTN3A1 Protein, Human, Recombinant (His)
BTN3.1,butyrophilin subfamily 3 member A1,BTF5,BT3.1,CD2... |
Human | HEK293 Cells |
BTN3A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2. | |||
TMPY-05288 |
PLGF/PGF Protein, Human, Recombinant (aa 19-149)
PLGF,PGFL,placental growth factor,D12S1900,SHGC-107... |
Human | E. coli |
PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P49763-2. | |||
TMPY-02820 |
SDF-1 Protein, Human, Recombinant (isoform a)
SDF1,chemokine (C-X-C motif) ligand 12,IRH,SCYB1 |
Human | E. coli |
SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2. | |||
TMPY-01935 |
c-Kit Protein, Human, Recombinant (His)
PBT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog... |
Human | HEK293 Cells |
c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2. | |||
TMPY-04356 |
GSK3B Protein, Human, Recombinant (His)
glycogen synthase kinase 3 beta,glycogen synthase kinase 3 β |
Human | Baculovirus Insect Cells |
GSK3B Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.4 kDa and the accession number is P49841-2. | |||
TMPY-02500 |
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)
Gp39,AW208766,Brp39,chitinase 3 like 1 |
Mouse | HEK293 Cells |
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.3 kDa and the accession number is Q61362-2. | |||
TMPY-04396 |
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k... |
Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... | |||
TMPY-01985 |
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated
FCGR2,FCGR21,CD32A,FCG2,... |
Human | HEK293 Cells |
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2. | |||
TMPY-04644 |
PDGFB Protein, Human, Recombinant (His)
platelet-derived growth factor beta polypeptide,SSV,c-sis,SI... |
Human | P. pastoris (Yeast) |
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted... | |||
TMPY-05414 |
NKG2D/CD314 Protein, Mouse, Recombinant (hFc)
D6H12S2489E,NKG2-D,killer cell le... |
Mouse | Baculovirus Insect Cells |
NKG2D/CD314 Protein, Mouse, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is O54709-2. | |||
TMPY-01871 |
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)
interleukin 5 receptor, alpha,IL5R,CD125,CDw12<... |
Human | HEK293 Cells |
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is Q01344-2. | |||
TMPY-02792 |
GDNF Protein, Human, Recombinant (HEK293)
HSCR3,ATF2,HFB1-GDNF,ATF1,glial cell derived neurot... |
Human | HEK293 Cells |
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2. | |||
TMPY-01888 |
KRAS Protein,Human, Recombinant (Q61H, His)
KRAS2,C-K-RAS,Kirsten rat sarcoma viral oncogene ho... |
Human | E. coli |
KRAS Protein,Human, Recombinant (Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P01116-2. | |||
------------------------ 更多 ------------------------ |